Premium
The Protective Effect of β1–3D‐Glucan‐Derivatized Plastic Beads against Escherichia coli Infection in Mice
Author(s) -
SELJELID R.,
RASMUSSEN L.T.,
LARM O.,
HOFFMAN J.
Publication year - 1987
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1987.tb01046.x
Subject(s) - escherichia coli , glucan , microbiology and biotechnology , bacteria , chemistry , biology , biochemistry , gene , genetics
Pretreatment with β‐1, 3‐D‐glucan‐derivated plastic beads conferred strong protection against Escherichia coli infection in mice. The protective effect showed a dose‐response relationship to the amount of beads injected and was dependent on the time point of the injection relative to the infection with E. coli. A similar protection could be obtained in nude mice. Experiments with radioactively labelled bacteria as well as beads indicated a systemic effect of the beads. macrophages extracted from animals treated with glucan plastic beads appeared highly stimulated. This was also true of cells that did not contain beads and presumably therefore not glucan, which seems to indicate a soluble stimulatory factor.