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A Hypothesis for the Selection of Available Repertoires: T‐Cell Network Early in the Intrathymic Differentiation
Author(s) -
HERA A. DE LA,
TORIBIO M. L.,
MARCOS M. A. R.,
MARQUEZ C.,
MARTINEZA C.
Publication year - 1986
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1986.tb02182.x
Subject(s) - biology , t cell receptor , major histocompatibility complex , thymocyte , t cell , receptor , antigen , microbiology and biotechnology , cellular differentiation , immunology , gene , genetics , immune system
T‐cell recognition requires direct cell‐cell interactions mediated by major histocompatibility complex (MHC)‐restricted α‐β heterodimeric receptors (Ti) in association with a constant protein complex termed T3 (TcR, Ti‐T3). Interleukin 2 (IL‐2) promotes growth and maturation of T cells upon binding to high affinity receptors (IL2‐R). They are expressed after the recognition of antigen on accessory cells through the TcR [44]. Furthermore, current hypotheses propose that T‐cell interactions are also mediated by a group of T‐cell antigens, particularly T4/L3T4 and T8/Lyt 2 [35], and perhaps Tγ [15]. All their encoding genes are rearranged and/or expressed sequentially during thymocyte differentiation [5, 8, 40, 41, 46, 51, 52]. Thus, developmental analyses of T‐cell function are essential to gain insight into the mechanisms for selection of available repertoires, one of the central problems in immunology.