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Functional Competence of Dendritic Cells of Ageing C57BL/6 Mice
Author(s) -
KOMATSUBARA S.,
CINADER B.,
MURAMATSU S.
Publication year - 1986
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1986.tb02166.x
Subject(s) - ageing , immune system , immunology , c57bl/6 , inbred strain , dendritic cell , biology , microbiology and biotechnology , chemistry , genetics , gene
Highly poly morphic age‐dependent differences in progression of T and B cells have been found in various strains of inbred mice. In the immune system of C57BL/6 mice these occur first in B cells and, later in life, in T cells. In this paper, we have examined the progression in the functional capacity of C57BL/6 dendritic cells (DC). Age‐dependent changes were found in the syngeneic mixed leucocyte reaction, in which the stimulatory capacity of DC increased with age. This increase was independent of the age of the donor of the serum that was added to the culture, and occurred when young donors provided the T cells. Age‐dependent changes in DC properties were not detected in terms of direct plaque‐forming response, response to con‐canavalin A, or in the allogeneic mixed leucocyte reaction.