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Monoclonal Antibodies Specific for Sendai Virus
Author(s) -
FENNER M.,
SIEGMANN K.,
BINZ H.
Publication year - 1986
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1986.tb02103.x
Subject(s) - polyclonal antibodies , sendai virus , monoclonal antibody , idiotype , epitope , antiserum , antibody , virology , monoclonal , immunoglobulin idiotypes , microbiology and biotechnology , biology , virus , immunology
The monoclonal antibodies A and B specific for the HN molecule of Sendai virus were used to induce polyclonal and monoclonal anti‐idiotypic antibodies. No response was observed in allogeneic Lewis rats, low responses in syngeneic LOU rats, and high responses in allogeneic BN rats and xenogeneic Balb/c mice. The monoclonals A and B share a similar or identical idiotype. since polyclonal anti‐idiotypic antisera to antibody A cross‐reacted completely with antibody B and vice versa. The same was found with the three monoclonal anti‐idiotypes 1, 2, and 3elicited in a BN rat or in Balb/c mice. None of the polyclonal or monoclonal anti‐idiotypes reacted with other monoclonal antibodies specific for Sendai virus, even when these recognized the same epitope as antibodies A and B. The monoclonal anti‐idiotypic antibodies could be used to induce anti‐Sendai antibodies in BN rats.