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Correlation between the Phenotype and the Functional Capacity of Activated T Cells in Patients with Active Systemic Lupus Erythematosus
Author(s) -
VOLK H.D.,
KOPP J.,
KÖRNER I. J.,
JAHN S.,
GRUNOW R.,
BARTHELMES H.,
FIEBIG H.
Publication year - 1986
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1986.tb02074.x
Subject(s) - immunology , antigen , monoclonal antibody , phenotype , antibody , systemic lupus erythematosus , in vitro , peripheral blood , medicine , disease , lupus erythematosus , biology , gene , biochemistry
Activated T cells in the peripheral blood of patients with systemic lupus erythematosus (SLE) were determined using monoclonal antibodies against activation antigens. Elevated percentages of HLA‐DR + T cells were found in association with active disease. In contrast, we observed an increase in IL‐2, receptor‐bearing T cells in only six out of 16 patients with active disease. In vitro assays, like spontaneous proliferation, response to IL‐2, production of IL‐2, and immunoglobulin synthesis have shown that the different patterns of activation antigens are related to different functional stages of T‐cell activation. The possible therapeutic consequences are discussed.