Premium
Monocyte‐T‐Cell Interactions in the Regulation of Polyclonal B‐Cell Response
Author(s) -
PRYJMA J.,
FLAD H.D.,
GRUBER M.,
ERNST M.
Publication year - 1986
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1986.tb02065.x
Subject(s) - monocyte , polyclonal antibodies , suppressor , t cell , biology , antibody , fc receptor , pokeweed mitogen , microbiology and biotechnology , immunology , in vitro , peripheral blood mononuclear cell , immune system , gene , biochemistry
Human peripheral blood monocyte subsets with and without Fc receptor for human IgG are known to suppress (FcR + ) and enhance (FcR − ) pokeweed mitogen‐induccd polyclonal immunoglobulin synthesis in vitro. The ability of these subsets to modulate immunoglobulin production in the presence or absence OKT8 − T cells and under conditions where suppressor T‐cells activation was blocked by irradiation or mitomycin C was studied. It was shown that, regardless of the presence or absence of suppressor T cells, FcR − monocytes can suppress immunoglobulin production if their number in culture exceeds 20%. However, at lower numbers this monocyte sunset was suppressive only when suppressor T cells were activated. The suppressor T‐cell activation was shown to be independent of the predominant presence of the FcR + or FcR monocyte subset. Moreover, the enhancing effect of FcR − monocytes was not caused by their interference with suppressor T‐cell activation.