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Effects of Calmodulin Antagonists Cd 2+ and Trifluoperazine on Mixed Lymphocyte Culture Cell‐Mediated Lysis and Antibody‐Dependent Cell Cytolysis
Author(s) -
WOLFF C. H. J.
Publication year - 1986
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1986.tb02002.x
Subject(s) - trifluoperazine , cytolysis , lysis , antibody dependent cell mediated cytotoxicity , calmodulin , antibody , lymphocyte , immunology , biology , microbiology and biotechnology , cell , chemistry , biochemistry , cytotoxicity , in vitro , enzyme , monoclonal antibody
The effects of two substances with calmodulin‐antagonistic properties, cadmium and trifluoperazone, were studied on mixed lymphocyte culture‐cell mediated lysis (MLC‐CML) and antibody‐dependent cell cytolysis (ADCC). Both cadmium and trifluoperazine readily inhibited MLC‐CMC, while ADCC was inhibited only to a small extent or not at all. Trifluoperazine almost completely inhibited phagocytosis in cells whose ability to lyse antibody‐coated red blood cells was unimpaired. The results suggests a striking difference in the extent in which calmodulin mediated processes take part in MLC‐CML on the one hand and ADCC on the other. This indicates a profound dissimilarity in the mechanisms of these two types of cell‐mediated lysis.