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Bone Marrow Transplantation in the Rat
Author(s) -
RENKONEN R.,
HÄYRY P.
Publication year - 1986
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1986.tb01975.x
Subject(s) - inflammation , bone marrow , parenchyma , pathology , transplantation , lung , spleen , bone marrow transplantation , precursor cell , biology , medicine , immunology , cell , genetics
We have analysed the cytological structure of inflammation in the different parenchymal target organs during acute graft‐versus‐host disease after bone marrow transplantation in the rat. Inflammation (recovery of increased numbers of white cells) was recorded in the liver, skin, and lungs of the allograft recipient compared with the syngeneic graft recipient from day 5 onwards, accompanied by reduced recovery of inflammatory cells from the gut. The major cytological manifestation of the disorder was an increase in the total number of blast cells, large granular lymphocytes (LGL), and lymphocytes in the liver and skin, and of the number of blast cells and LGL in the lung. At the same time, a depletion of LGL and lymphocytes was recorded in the blood, suggesting migration of these cell components to the site of inflammation.