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Studies on the Mechanism of Binding and Uptake of Immune Complexes by Various Cell Types of Rat Liver in Vivo
Author(s) -
LAANKLAMER S. M.,
HARMS G.,
ATMOSOERODJO J. E.,
MEIJER D. K. F.,
HARDONK M. J.,
HOEDEMAEKER P. J.
Publication year - 1986
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1986.tb01950.x
Subject(s) - heterologous , in vivo , receptor , immune system , kupffer cell , antibody , in vitro , endothelial stem cell , biology , microbiology and biotechnology , cell , chemistry , biochemistry , immunology , gene
Soluble heterologous immune complexes (IC) were used to study the mechanism of IC binding to rat liver in vivo. Binding of IC to the various cell types of the liver, endothelial cells, hepatocytes. and Kupffer cells, was only inhibited by aggregated swine immunoglobulins. Binding was not inhibited by the absence of complement components. Intravenous injection of asialoglycoproteins. to block the galactose receptor, could not prevent IC binding. We conclude that Fc receptors play an important role in the binding of soluble heterologous IC to hepatocytes. endothelial cells, and Kupffer cells.