Premium
Lymphocyte Activation in Rheumatoid Arthritis Synovial Fluid in Vivo
Author(s) -
KONTTINEN Y.,
BERGROTH V.,
NYKÄNEN P.
Publication year - 1985
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1985.tb01909.x
Subject(s) - cytotoxic t cell , synovial fluid , synovial membrane , tcirg1 , immune system , in vivo , immunology , lymphocyte , effector , rheumatoid arthritis , t cell , biology , chemistry , microbiology and biotechnology , il 2 receptor , medicine , in vitro , pathology , biochemistry , alternative medicine , osteoarthritis
Monoclonal antibodies were used in avidin‐biotin‐peroxidase complex staining for activation marker analysis of rheumatoid synovial fluid cells. Although Ia expression indicates T cell activation, cells displaying receptors for interleukin 2 (Tac)‐and transferrin receptor (T9)‐ positive proliferating cells were relatively few. Similarly, activated terminal effector cells of suppressor/cytotoxic nature were scarce in rheumatoid synovial fluid, as suggested by a low expression of Tac and 4F2 markers. The in vivo situation in the rheumatoid arthritic (RA) joint does not seem to be due to the inability of synovial fluid lymphocytes to become activated, because mitogen stimulation in vitro, in spite of a low proliferative response, induced expression of all the activation markers studied. The relevance of the present observations to the down‐regulation of the active, inflammatory‐immune response in situ is speculative, but the data show that in spite of T‐cell activation and Ia expression, activated terminal effector cells of suppressor/cytotoxic nature are few in the RA joint in vivo.