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Augmentation of Natural Killer Cell Activity by Anti‐Host Delayed‐Type Hypersensitivity during the Graft‐versus‐Host Reaction in Mice
Author(s) -
McI A.,
MOWAT A.,
BORLAND A.,
PARROTT D. M. V.
Publication year - 1985
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1985.tb01897.x
Subject(s) - graft vs host reaction , spleen , effector , immunology , biology , hypersensitivity reaction , host (biology) , natural killer cell , in vitro , cytotoxicity , bone marrow , bone marrow transplantation , genetics
During a graft‐versus‐host (GVH) reaction in unirradiated F 1 hybrid mice there is a generalized activation of natural killer (NK) cells. We have examined whether the enhanced NK activity is due to an F 1 resistance mechanism directed at the parental cells used to induce the GVH reaction. Spleen cells of C57BL/10 origin induce much more NK cell activation in B10F 1 hybrids than the opposite parental type, despite a similar intensity of systemic GVH reactions. However, this does not correlate with in vivo resistance of mice with GVH reaction to a local challenge dose of B10 cells. NK cell activation in (CBA xBALB/c)F 1 mice with GVH reaction involves both host and donor cells and is preceded by an anti‐host delayed‐type hypersensitivity (DTH) response. B10 cells have a greater ability to induce DTH in B10F 1 mice than cells from the opposite parent. We propose that NK cells are one group of non‐specific effector cells recruited by DTH in a GVH reaction and may contribute to the tissue pathology.