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Production of Interleukin 1 but not of Procoagulant Activity by Large Granular Lymphocytes
Author(s) -
RAMBALDI A.,
ALESSIO G.,
ROSSI V.,
DONATI M. B.,
SEMERARO N.,
MANTOVANI A.
Publication year - 1985
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1985.tb01893.x
Subject(s) - monocyte , cytotoxicity , immunology , macrophage , interleukin , biology , phenotype , chemistry , microbiology and biotechnology , cytokine , in vitro , biochemistry , gene
Large granular lymphocytes (LGL) share phenotypic and functional properties with monocytes. We have investigated the production of procoagulant activity (PCA), so far attributed to cells of the monocyte‐macrophage lineage, by LGL. Endotoxin triggered interleukin (I L‐1) release and PCA activity by highly purified monocyte preparations. In contrast, LGL exposed to endotoxin produced IL‐1 but had no PCA activity. Similarly ineffective in inducing PCA in LGL were other stimuli that either triggered monocyte PCA or stimulated the natural killer cytotoxicity of LGL. Thus, although LGL share properties with monocytes such as the capacity to produce IL‐1, PCA is confined, among circulating leukocytes, to cells of the monocyte lineage.