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In Vivo Activation of Mouse Macrophages with β‐l,3‐D‐Glucan‐Derivatized Plastic Beads
Author(s) -
SELJELID R.,
BØGWALD J.,
RASMUSSEN L.T.,
LARM O.,
HOFFMAN J.,
BERGE A.,
UGELSTAD J.
Publication year - 1985
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1985.tb01850.x
Subject(s) - in vivo , in vitro , glucan , ascites , chemistry , peritoneal cavity , microbiology and biotechnology , biology , biochemistry , medicine , anatomy
Macrophages obtained from animals treated withβ‐1.3‐D‐glucan‐derivatized plastic beads were greatly stimulated, as judged by morphology, esterase release, and cytostatic effect on L‐929 tumour cells in vitro. The pretreatment of mice with such heads conferred an apparent absolute local resistance to an otherwise lethal pneumococcal infection but had no effect on the growth of intrapcritoneal AA ascites sarcoma. Moreover, peritoneal cells from animals pretreated with glucan beads did nut protect the animals in a Winn assay.