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Studies of Monoclonal Antibodies Specific for Major Histocompatibility Complex Products of the Rat
Author(s) -
HEMMI S.,
FENNER M.,
BINDER C.,
BINZ H.,
WINTERHALTER K.,
WIGZELL H.
Publication year - 1985
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1985.tb01846.x
Subject(s) - monoclonal antibody , polyclonal antibodies , antibody , monoclonal , idiotype , antigen , immunology , biology , microbiology and biotechnology , major histocompatibility complex , immune system , virology
Polyclonal anti‐idiotypic antibodies against monoclonal antibodies with specificity for RT1‐encoded antigens were induced in syngeneic, allogeneic, and xenogeneic hosts. The immune response to the idiotypic determinants on monoclonal antibodies was T‐cell‐dependent. The anti‐idiotypic antibodies, independent of whether they were induced in syngeneic, allogeneic, or xenogeneic (after proper absorption) hosts, showed an exquisite specificity for the monoclonal antibody used for the induction. No cross‐reactivity with other monoclonal antibodies could be observed.