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Enriched Langerhans Cells Express More HLA‐DR Determinants Than Blood‐Derived Adherent Cells (Monocytes and Dendritic Cells)
Author(s) -
BJERCKE S.,
GAUDERNACK G.,
BRAATHEN L. R.
Publication year - 1985
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1985.tb01837.x
Subject(s) - immunology , human leukocyte antigen , hla dr , monocyte , biology , microbiology and biotechnology , antigen
When used as antigen‐presenting cells, enriched Langerhans cells (LC) are known to induce a stronger proliferative T‐cell response towards antigens than blood‐derived adherent cells (a mixture of monocytes and dendritic cells). To study the mechanism behind this difference in accessory cell function, we have compared the quantitative expression of HLA‐DR molecules on LC and adherent cells (AdC), using a radioimmunoassay system. The amount of HLA‐DR determinants was calculated to be 50–100 times higher on LC than on AdC.