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Langerhans Cells and Extra‐Epidermal Dendritic Cells
Author(s) -
ROWDEN G.,
BOUDREAU S.,
HIGLEY H.
Publication year - 1985
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1985.tb01834.x
Subject(s) - follicular dendritic cells , histiocyte , epidermis (zoology) , lymph node , pathology , birbeck granules , spleen , biology , dendritic cell , cytoplasm , reticular cell , peripheral blood mononuclear cell , macrophage , lymph , microbiology and biotechnology , lymphatic system , antigen presenting cell , langerhans cell , immunology , antigen , t cell , immune system , medicine , anatomy , in vitro , biochemistry
S‐100 protein was demonstrated in the cytoplasm of dendritic cells (DCs) in normal and pathologic lymphoid tissues and epidermis in man and several other species. The presence of S‐100) protein served to distinguish these cells from other mononuclear cells, most importantly from those of macrophage/histiocyte lineage. Fractionation procedures to isolate and enrich suspensions of DCs were coupled with immunocytochemical techniques to identify S‐100‐positive cells. Langerhans cells in the epidermis and in aural cholesteatomata and nodal, splenic, and thymic interdigitating cells were S‐100‐positive. Lymph node and splenic follicular dendritic cells (except in rats) were negative, indicating that this DC may be a separate cell type.