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Adherence of Lysostaphin to and Penetration into Human Monocytes
Author(s) -
BROEK P. J.,
BUYS L. F. M.,
FURTH R.
Publication year - 1985
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1985.tb01419.x
Subject(s) - lysostaphin , staphylococcus aureus , monocyte , penetration (warfare) , microbiology and biotechnology , incubation , in vitro , chemistry , immunology , biology , bacteria , biochemistry , genetics , operations research , engineering
The effect of lysostaphin on Staphylococcus aureus phagocytosed by monocytes was investigated. The results showed that lysostaphin adheres to monocytes by a temperature‐independent mechanism, is not adequately removed from monocytes by washing, and penetrates by means of a temperature‐dependent mechanism. In in vitro assays of monocyte function, phagocytosed S. aureus can be killed by lysostaphin after penetration of the cells during incubation or by adhering lysostaphin when the monocytes are disrupted.