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Development of Natural Killer Cells: Comparison of the Maturation Rates in Different Lymphoid Compartments
Author(s) -
HURME M.,
SIHVOLA M.
Publication year - 1985
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1985.tb01415.x
Subject(s) - spleen , biology , transplantation , bone marrow , lymphokine activated killer cell , immunology , bone marrow transplantation , natural killer cell , cell , interleukin 21 , immune system , medicine , t cell , in vitro , cytotoxicity , biochemistry , genetics
By means of semisyngeneic bone marrow transplantation, the appearance of donor‐type natural killer (NK) cells in different organs (spleen, blood, lungs) of the recipients was studied. Seven days after the transplantation the first donor‐type NK cells appeared in all these organs, and adult NK levels were reached simultaneously within a couple of days. The first NK cells to appear in every organ divided rapidly (sensitive to hydroxyurea) and contained a high proportion of Thy‐1 + cells. These data suggest that NK cell precursors mature locally and simultaneously in different organs.