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Effect of Verapamil on T‐Lymphocyte Activation in Vitro
Author(s) -
BRUSERUD Ø.
Publication year - 1985
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1985.tb01405.x
Subject(s) - verapamil , phytohaemagglutinin , in vitro , pharmacology , mixed lymphocyte reaction , interleukin 2 , calcium , chemistry , inhibitory postsynaptic potential , drug , endocrinology , medicine , immunology , immune system , biology , t cell , biochemistry
Verapamil, a calcium‐inhibitory drug, was found to inhibit T‐lympocyte proliferation in mixed lymphocyte culture and the proliferate response to phytohaemagglutinin and mumps antigen. It also inhibited production of interleukin 2 (IL‐2). To exert inhibition, verapamil had to he added early in the culture period. Verapamil also had a relatively small inhibitory effect on IL‐2‐dependent growth. The effects were clearly seen only at concentrations exceeding the therapeutic serum level of verapamil.