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In Vitro Induction of Specific T Cells Able to Help in the Generation of Delayed‐Type Hypersensitivity by Thymus‐Dependent and Type‐II ‘Thymus‐Independent’ Antigens
Author(s) -
BRETSCHER P. A.
Publication year - 1984
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1984.tb01034.x
Subject(s) - hapten , antigen , in vitro , immunology , delayed hypersensitivity , biology , microbiology and biotechnology , genetics
An in vitro system is described which supports the primary induction of T cells able to help in the induction of delayed‐type hypersensitivity. This system is used to demonstrate that hapten‐Ficoll conjugates induce potent hapten‐specific T cells with this function. These type‐II ‘thymus‐independent’ antigens are thus able to induce specific regulatory T cells. These helper T cells are similar to those induced by classical thymus‐dependent antigens in that they are specific for antigen rather than idiotype and act by a linked mechanism.