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Role of Ia‐Positive Cells in the Lymphocyte Responses to Yersinia
Author(s) -
VUENTO R.,
ESKOLA J.,
LEINO R.,
VIANDER M.,
TOIVANEN A.
Publication year - 1984
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1984.tb00987.x
Subject(s) - yersinia , immunology , antigen , t lymphocyte , lymphocyte , pathogenesis , reactive arthritis , arthritis , biology , microbiology and biotechnology , bacteria , genetics
Activation of T lymphocytes by an antigen requires joint recognition of the‐ antigen and the class‐H HLA determinants on the membrane of the antigen‐presenting cells (APC). Patients with reactive arthritis exhibit a depressed lymphocyte transformation response 10 Yersinia , suggesting a possible immunoregulatory disturbance in these patients. In this study the role of Ia (dass‐II HLA antigen)‐positive APC in the lymphocyte response to a complex antigen, whole Yersinia bacterium, was evaluated. The results demonstrate that Ia‐positive cells are necessary for the T‐lymphocyte response to Yersinia . The role of APC in the pathogenesis of reactive arthritis is discussed.