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Receptor‐like Activity of a Monoclonal Anti‐Idiotypic Antibody against an Anti Acetylcholine Receptor Antibody
Author(s) -
LEFVERT A. K.,
FULPIUS B. W.
Publication year - 1984
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1984.tb00958.x
Subject(s) - acetylcholine receptor , monoclonal antibody , myasthenia gravis , idiotype , receptor , antibody , chemistry , immunoglobulin idiotypes , microbiology and biotechnology , biology , biochemistry , immunology
A monoclonal anti‐idiotypic antibody against an anti‐acctylcholine receptor antibody from a patient with myasthenia gravis was shown to bind the cholinergie ligand α‐bungarotoxin. This binding could be inhibited by other cholinergic ligands. boih antagonists und agonists. The anti‐idioiype was also able to elicit the production of anti‐receptor antibodies in mice Thus, the anti‐idiotype had functional properties similar to those of the original antigen, the acetylcholine receptor.