Premium
Study of Activated T Cells in Man
Author(s) -
GUPTA S.
Publication year - 1984
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1984.tb00955.x
Subject(s) - antigen , in vitro , immunology , monoclonal antibody , t cell , t lymphocyte , microbiology and biotechnology , in vivo , antibody , peripheral blood , medicine , chemistry , biology , immune system , biochemistry
DR and Tac antigens are present on T cells activated in vitro with mitogens and antigens but lacking on resting T cells. Freshly prepared peripheral blood T cells from patients with common variable immunodeficiency (CVI) and isolated IgA deficiency (IAD) were examined for the presence of DR and Tac antigens, using monoclonal antibodies and a fluorescence‐activated cell sorter.‘Both Tac + and DR + T cells were significantly (P < 0.05) increased in the patient group when compared with age‐ and sex‐matched controls; however, a discrepancy was observed in the proportions of Tac + T cells and DR + T cells. This study demonstrates that, in certain patients with CVI and IAD, T cells are activated in vivo, and Tac and DR antigens could be expressed during different stages of T‐cell activation.