Premium
Different Fate of Antibodies to Surface IgM and IgD in Germinal Centre Cell‐Associated Lymphomas
Author(s) -
RUUD E.,
BEISKE K.,
DRACK A.,
STEEN H. B.,
GODAL T.
Publication year - 1984
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1984.tb00953.x
Subject(s) - immunoglobulin d , antibody , immunoglobulin light chain , germinal center , biology , heavy chain , b cell , microbiology and biotechnology , immunology
In all of four human germinal centre cell‐associated B lymphomas carrying sIgM + sIgD F(ab') 2 fragments of rabbit antibodies to human μ‐chain were accumulated intracellularly, whereas the accumulation of antibodies to δ‐chain was considerably less abundant. The accumulation of antibodies to light chain was intermediate between antibodies to μ‐ and δ‐chain. These results could be explained by the following observations: (i) the difference in the level of reexpression of sIgM and sIgD and (ii) the discovery that antibodies to δ‐chain bound to reexpressed sIgD were degraded at a higher rate than those bound to primary sIgD and at a higher rate than antibodies to μ‐chain, whether hound to primary or reexpressed sIgM.