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T‐Cell Proliferation and Expression of MHC Class II Antigens
Author(s) -
BROWN G.,
WALKER L.,
LING N.R.,
RICHARDSON P.,
JOHNSON G.D.,
GUY K.,
STEEL C.M.
Publication year - 1984
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1984.tb00944.x
Subject(s) - antigen , major histocompatibility complex , monoclonal antibody , biology , microbiology and biotechnology , pan t antigens , t cell , mhc class ii , gene , immunology , antibody , immune system , genetics
Two monoclonal antibodies to major histocompatibility complex (MHC) class II antigens, which in combination identify β chains encoded by the SB and DR loci, were used to investigate which of these gene‐ products were expressed at the cell surface of unstimulated T cells and at various stages of mitogen‐induced T‐cell maturation. In tests on blood lymphocytes from healthy donors 12% of Tcells expressed class II antigens, but only SB antigens were expressed. During activation of T lymphocytes, SB‐coded antigens were expressed before DR antigens, and the kinetics of SB expression correlated with the proliferative response of T cells. These results and consideration of recent reports from other laboratories lead us to suggest that 58‐coded class II antigens play a role in T‐cell proliferation.