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Alloreactive Cytotoxic T Lymphocytes Lyse Syngeneic Influenza‐Infected Tumour Cell Targets
Author(s) -
MÜLLBACHER A.,
ASHMAN R.B.,
ADA G.L.
Publication year - 1984
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1984.tb00943.x
Subject(s) - virus , biology , sendai virus , virology , cytotoxic t cell , spleen , monoclonal antibody , population , antigen , in vitro , antibody , immunology , medicine , biochemistry , environmental health
Spleen cells from C57BL/10(H‐2 b ) mice, when stimulated in vitro to K k alloantigens, lysed syngeneic influenza A virus‐infected tumour cell targets but not uninfected or vaccinia‐ or Sendai virus‐infected targets. Peritoneal macrophage targets infected with influenza virus were not lysed. Lysis of H‐2 k targets and EL4‐A influenza virus‐infected targets was abrogated by treatment of effectors with anti‐Thy 1.2plusCandanti‐Lyt2plusCbut not by anti‐Lyt 1 plusC or anti‐GM‐1. a natural killer cell‐specific, monoclonal antibody plus C. Cold target inhibition experiments indicated that one and the same population of Tc cells see H‐2K k and H‐2 b plus influenza virus. Sensitization of C57BL/10 mice to K k in vivo did not potentiate virus clearance from lungs. The data are discussed in relation to observed Ir gene effects and variation and modulation of H‐2 antigens on tumour cells.