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Decreased Cloning of Lymphocytes from Elderly Individuals
Author(s) -
CHRYSOSTOMOU A.,
SESHADRI R.,
MORLEY A. A.
Publication year - 1984
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1984.tb00933.x
Subject(s) - cloning (programming) , clone (java method) , limiting , biology , lymphocyte , immunology , microbiology and biotechnology , genetics , gene , computer science , mechanical engineering , engineering , programming language
Limiting‐dilution cloning of human lymphocytes was used to study cloning and proliferation of lymphocytes in 10 young and 10 elderly individuals. The cloning efficiency for elderly individuals, 3.5%, was significantly lower than that for young individuals, 19.8%. Mixing experiments showed that this decrease was due to both a decrease in the frequency of the clone‐forming cells and a decrease in the interacting ability of the lymphocytes. Lymphocytes from elderly individuals which did form clones, however, proliferated at the same rate as did those from young individuals.