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HLA Class‐II‐Specific T‐Lymphocyte Clones with Dual Alloreactive Functions
Author(s) -
FLOMENBERG N.,
DUFFY E.,
DUPONT B.
Publication year - 1984
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1984.tb00925.x
Subject(s) - human leukocyte antigen , cytotoxic t cell , immunology , antigen , biology , population , cytotoxicity , t lymphocyte , t cell , immune system , genetics , medicine , in vitro , environmental health
The relationship between T lymphocytes that proliferate in response to HLA class II antigens and those that mediate the cytotoxic response toward HLA class II target antigens was investigated. Alloreactive T‐cell clones were derived under conditions in which the likelihood of clonality was high. Three populations of HLA class‐II‐specific T cells were identified. Two of these populations exhibited only HLA class‐II‐directed cytotoxicity or HLA class‐II‐induced proliferation. The third population of T cells exhibited both of these responses.