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Genetic Control of the Murine IgM Plaque‐Forming Cell Response to Type III Pneumococcal Polysaccharide
Author(s) -
PASANEN V. J.,
MÄKELÄ O.
Publication year - 1984
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1984.tb00907.x
Subject(s) - congenic , biology , inbred strain , recombinant dna , gene , spleen , microbiology and biotechnology , genetics , immunology
The direct 5‐day plaque‐forming cell response of different inbred mouse strains to pneumococcal polysaccharide type III (SSS‐III) varied from more than 10,000 per spleen, in BALB/c mice, to less than 2000 in C57BL mice. Responses of Igh congenic and recombinant inbred lines bearing different combinations of BALB/c and C57BL genes indicate that two or more gene loci are involved in controlling high or low responses. At least one is in the Igh‐V region since BALB/c, BAB‐14, and CB‐8 KN mice (Igh‐V 2 ) had two to four times higher responses than CB‐20 and CB‐16 KN mice (Igh‐V b ). Other gene loci must be involved, but nothing can be said about them at present.