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Residual Minor Histocompatibility Genes Contaminate the B10. AM Congenic Line: No Evidence of C‐Region‐Controlled Histoincompatibility
Author(s) -
JURETIĆ A.,
PROTRKA N.,
WALDEN P.,
NAGY Z. A.,
KLEIN J.
Publication year - 1983
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1983.tb00886.x
Subject(s) - ctl* , congenic , locus (genetics) , biology , allele , genetics , antigen , major histocompatibility complex , histocompatibility , gene , microbiology and biotechnology , human leukocyte antigen , cd8
After being primed in vivo and restimulated in vitro, cytolytic T lymphocytes (CTL) were produced in the strain combinations B10.AM ami‐B10.A(1R) and B10.A(1R) anti‐B10.AM. Although the two strains differ in the chromosomal interval between the E α and the D loci, the CTL are not directed against antigens controlled by loci in this interval. Instead, the CTL detect minor histocompatibility (H) antigens controlled by loci that are notlinked to H‐2 . The recognition of the antigens detected by the B10. AM anti‐B10.A(lR) CTL is restricted by the K k and D b molecules, but the CTL also cross‐react with the D d molecule (or a molecule controlled by a locus closely linked to D d ). The recognition of the antigens detected by these two CTL behave as if controlled by alleles at the same minor H locus or loci. This locus is distinct from H‐2 , and the B 10. AM congenic line apparently retained a C3H‐derived allele at this locus.