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Anti‐IgA in Selective IgA Deficiency
Author(s) -
HAMMARSTROM L.,
PERSSON M. A. A.,
SMITH C. I. E.
Publication year - 1983
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1983.tb00885.x
Subject(s) - iga deficiency , selective iga deficiency , antibody , polyclonal antibodies , immunology , pathogenesis , immunoglobulin a , secretory iga , biology , medicine , immunoglobulin g
Anti‐IgA antibodies were found in 14 of 33 (42%) IgA‐deficient donors. In healthy IgA‐deficient blood donors anti‐IgA appeared associated with the presence of HLA DR3. The antibodies were mainly of the IgG1 and, in high‐titred sera, IgG4 subclasses. Sera containing high‐titred anti‐IgA selectively impaired IgA synthesis in vitro as induced by direct and indirect polyclonal B‐cell activators. These antibodies may play a role in the pathogenesis and/or the maintenance of IgA deficiency.