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An OKT4 + T‐Cell Population with Suppressor Activity in Sézary Syndrome
Author(s) -
FARNARIERSEIDEL C.,
KAPLANSKI S.,
GOLSTEIN M.M.,
JANCOVICI E.,
SAYAG J.,
DEPIEDS R.
Publication year - 1983
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1983.tb00870.x
Subject(s) - suppressor , population , t cell , cell , cancer research , medicine , immunology , biology , genetics , gene , immune system , environmental health
This report describes a case of Sézary syndrome with the surface marker phenotype of a mature distinct T‐cell subset OKT3 + . OKT4 + . OKT8 − . OKT17 + . OKIal −(+) . Functional studies indicated that the patient's peripheral blood cells showed a very low proliferative response to non‐specific milogens (phytohaemagglutinin. concanavalin A. pokeweed mitogen) and failed to differentiate into plasma cells in a pokeweed mitogen—immunoglobulin‐synthesis‐driven system. In coculture with normal cells the leukuemic cells were able to suppress lectin‐induced T‐cell proliferation and B‐cell differentiation in a dose‐dependent manner. Suppressor function was not radiosensitive and did not require the presence of the OKT8 + subset for expression. These Sézary cells thus represent a suppressive T‐cell subset within the OKT4 + population. This subset may well correspond to the recently described OKT4 + . OKT17 + normal suppressor cells. These findings would therefore illustrate a pathological and possibly clonal expansion of a normal OKT4 + suppressor T‐ceil subset.