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The Role of Calmodulin in Human Natural Killer Cell Activity
Author(s) -
MOON T. D.,
MORLEY J. E.,
VESSELLA R. L.,
LANGE P. H.
Publication year - 1983
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1983.tb00865.x
Subject(s) - calmodulin , lytic cycle , calcium , calcium in biology , intracellular , chemistry , microbiology and biotechnology , potency , biological activity , biology , biochemistry , immunology , in vitro , virus , organic chemistry
Calcium is known to play an essential role in the lytic mechanism of natural killer cells (NK), which form a subset of large granular lymphocytes. Many of the intracellular effects of calcium are mediated through the calcium‐binding protein calmodulin. In this study we have demonstrated that the specific calmodulin inhibitors (naphthalene‐sulphonamides) inhibit NK activity in humans at IC 50 's of 6.9 μM for W7 and 5.2 μM for W13. Comparison of the potency of these compounds with their less active counterparts suggests that NK activity is calmodulin‐dependent.