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Evaluation of the Inbred Mouse as a Model for Experimental Treponema pallidum Infection
Author(s) -
FOLDS J. D.,
RAUCHBACH A. S.,
SHORES E.,
SAUNDERS J. M.
Publication year - 1983
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1983.tb00858.x
Subject(s) - treponema , antibody , inoculation , biology , microbiology and biotechnology , inbred strain , virology , hemagglutination , immunology , syphilis , gene , genetics , human immunodeficiency virus (hiv)
Mice of several inbred strains were studied for responses to Treponema pallidum (Nichols). Mice were injected with viable treponemes and observed daily for the presence of lesions or signs of illness. Although none of the mice developed detectable lesions, they did develop specific anti‐T. pallidum antibodies that were observed as early as 21 days after inoculation with viable T. pallidum . The antibodies were detected by an enzyme‐linked immunosorbent assay and by passive haemagglutination.