Premium
Cellular Responses to Bacterial Lipopolysaccharide: LPS Facilitates Priming of Antigen‐Reactive T Cells
Author(s) -
MILNER E.C.B.,
RUDBACH J.A.,
VONESCHEN K.B.
Publication year - 1983
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1983.tb00832.x
Subject(s) - lipopolysaccharide , priming (agriculture) , antigen , ovalbumin , adjuvant , immunology , microbiology and biotechnology , in vitro , cell , biology , chemistry , biochemistry , botany , germination
The effect of bacterial lipopolysaccharide (LPS) on the capacity of mice to mount a specific T‐cell response to a protein antigen was examined. Inoculation of mice with LPS and ovalbumin (OA) resulted in enhancement of the T‐cell proliferative response to OA. This enhancement was manifested in vitro by an increase in magnitude and by a more rapid appearance of the response after challenge with OA. This enhancement was also shown because the latent periods for the antigen‐specific responses were reduced to 3 days after inoculation with antigen plus LPS, as compared with 5 days after inoculation with antigen alone. Various mouse strains, including the C3H/HeJ and C57BL/10ScN strains, responded to the adjuvant action of LPS at the T‐cell level. Results suggest that LPS exerts this adjuvant effect by facilitating clonal expansion of antigen‐reactive T cells during priming