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Lyt‐Phenotype Conversion of Cytotoxic T Lymphocytes Specific for the A and E Class II Major Histocompatibility Complex Molecules
Author(s) -
VIDOVIC D.,
SIMON M.M.,
NAGY Z. A.,
KLEIN J.
Publication year - 1983
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1983.tb00827.x
Subject(s) - cytotoxic t cell , phenotype , major histocompatibility complex , biology , histocompatibility , immunology , class (philosophy) , genetics , human leukocyte antigen , antigen , gene , in vitro , computer science , artificial intelligence
The Lyt‐l + (high) Lyt‐2 ± (low) primary cytotoxic T lymphocytes (CTL) specific for A(A α A β ) molecules and the Lyt‐l + Lyt‐2 + primary E(E α E β )‐specific CTL are both shown to become Lyt‐l − Lyt‐2 + effector cells after secondary in vitro stimulation. Thus CTL specific for class II major histocompatibility complex molecules exhibit the same Lyt‐phenotype shift as class‐I‐specific CTL do. The data suggest that either both class‐I‐specific and class‐II‐specific CTL follow the same differentiation pathway or regulatory cellular interactions allow only Lyt‐l − Lyt‐2 + cells to differentiate to secondary CTL.