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Origin of Peripheral Blood Macrophages in Bursa‐Cell‐Reconstituted Chickens
Author(s) -
VAINIO O.,
PECK R.,
KOCH C.,
TOIVANEN A.
Publication year - 1983
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1983.tb00782.x
Subject(s) - antigen , biology , antibody , macrophage , major histocompatibility complex , b cell , immunology , adoptive cell transfer , microbiology and biotechnology , cell , immune system , t cell , virology , in vitro , biochemistry , genetics
MHC class‐I antigens on peripheral blood macrophages and bursa cells were analysed after adoptive bursa cell transfer to cyclophosphamide‐treated immunodeficient chickens. We studied the expression of B‐F locus‐encoded antigens (B‐F is homologous to mouse H‐2K, D) on macrophages and B cells and found that macrophage B‐F antigens are of host origin, whereas bursa cells express only donor‐type B‐F antigens. Both syngeneic and allogeneic bursa cells restored IgM antibody production to a T‐cell‐independent antigen, Brucella , but only syngeneic bursa cells could restore the IgG antibody response to a thymus‐dependent antigen, sheep erythrocytes. The results indicate that B‐cell maturation and macrophage‐B‐cell interaction are not MHC‐restricted but that a restriction exists in T‐cell‐B‐cell collaboration.