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Different Responses Elicited in Vitro by Antibodies to IgM and IgD in Cells from a Surface IgM + D‐Positive Human Follicular Lymphoma
Author(s) -
RUUD E.,
STEEN H. B.,
BEISKE K.,
GODAL T.
Publication year - 1983
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1983.tb00778.x
Subject(s) - immunoglobulin d , antibody , lymphoma , follicular lymphoma , germinal center , dna synthesis , immunoglobulin light chain , in vitro , dna , microbiology and biotechnology , follicular phase , b cell , thymidine , cytoplasm , immunology , cell , biology , chemistry , endocrinology , biochemistry
The effect of anti‐Igs in combination with the tumour promoter TPA on DNA and Ig synthesis in a human follicular germinal centre cell lymphoma carrying slgM and slgD was investigated. The lymphoma cells responded to both amiti‐μ and anti‐γ chains and to anti‐δ light chains by DNA synthesis, as measured by mcthy‐( 3 H)‐thymidine incorporation. Flow cytofluorometric measurements, however, showed that only anti‐μ chains induced marked increase in cytoplasmic Ig content. This result suggests that in certain B‐cell subsets the signals elicited via slgM and slgD are different.