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HLA‐D/DR Restriction of Langerhans Cell‐Dependent Antigen Activation of T Lymphocytes
Author(s) -
BERLE E. J.,
BRAATHEN L. R.,
THORSBY E.
Publication year - 1982
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1982.tb00758.x
Subject(s) - antigen , immunology , human leukocyte antigen , t cell , antigen presentation , hla dr , antigen presenting cell , t lymphocyte , biology , microbiology and biotechnology , immune system
In previous studies we have shown that the response of T cells to antigen presented by epidermal Langerhans cells (LC) is restricted by products of the HLA‐D region. An optimal antigen‐specific response required that the LC used for antigen presentation shared both, or at least one, of the D/DR determinants of the T‐cell donor. These studies were, however, disturbed by a strong allogeneic response induced by the foreign D/DR determinants of the LC. We report here that by separating the antigen‐specific T cells from those that are alloreactive, a clearer picture of the D/DR restriction phenomenon may be obtained. Furthermore, the present studies demonstrate that the same D/DR determinants function as restriction elements on peripheral blood monocytes and LC.