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Potentiation of the PFC Response to Thymus‐Independent Antigens by Heterologous Erythrocytes
Author(s) -
WOOD C.,
FERNANDEZ C.,
MÖLLER G.
Publication year - 1982
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1982.tb00726.x
Subject(s) - heterologous , antigen , dextran , dinitrophenyl , immunology , long term potentiation , bovine serum albumin , horse , microbiology and biotechnology , chemistry , biology , antibody , biochemistry , receptor , gene , paleontology
Immunization with horse erythrocytes (HRBC) and a thymus‐independent (TI) antigen of the TI‐2 category, such as native dextran, dinitrophenyl‐dextran (DNP‐dextran), or DNP‐Ficoll, resulted in a three‐ to four‐fold enhancement of the plaque‐forming cell response to the TI antigen. The effect was found to be T‐cell‐associated, since cyclosporin A abrogated enhancement. The T cells or T‐cell factors involved were elicited early in the response to HRBC and acted on the initial stages of the TI response. The HRBC‐induced potentiation affected only B cells activated by the TI antigen; it could not induce a TI response when TI‐2 antigen was given under nonresponsive conditions; and it had only a slight effect on the response to a thymus‐dependent (TD) antigen. A soluble TD antigen, bovine serum albumin‐coupled dextran (BSA‐dextran), did not have potentiating ability equivalent to that of the paniculate HRBC. It was concluded that non‐specific T‐cell help can influence TI‐2 responses when they are present simultaneously.