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Receptors for the Third Complement Component on a Proportion of Large Granular Lymphocytes from Human Peripheral Blood
Author(s) -
NOCERA A.,
CADONI A.,
ZICCA A.,
PRIMIO R.,
LEPRINI A.,
FERRARINI M.
Publication year - 1982
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1982.tb00686.x
Subject(s) - azurophilic granule , receptor , biology , antibody , cytoplasm , complement receptor , microbiology and biotechnology , peripheral blood , immunology , complement system , biochemistry , myeloperoxidase , inflammation
Large granular lymphocytes (LGL) are nonadherent cells with cytoplasmic azurophilic granules, avid receptors for the Fc portion of IgG, and a paranuclear localization of alpha‐naphthyl acid esterase or acid phosphatasc. LGL constitute the bulk of T G cells (cells with receptors for sheep erythrocytes and for IgG molecules) and null cells (non‐T, non‐B cells). In the present study we demonstrate that 20–33% of the circulating human LGL express receptors for the third complement component (C3R). When T G cell or null cell fractions from normal individuals or non‐T cells from a patient with infantile agammaglobulinaemia (which contained almost exclusively LGL) were rosetted with erythro cytes coated with antibody and complement, a variable number of C3R‐bearing cells were detected. Such cells were isolated and analysed further; the great majority of them displayed the cytochemical and ultrastructural features of LGL.