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Relationships between HLA‐DR‐expressing Cells and T Lymphocytes of Different Subsets in Rheumatoid Synovial Tissue
Author(s) -
KLARESKOG L.,
FORSUM U.,
WIGREN A.,
WIGZELL H.
Publication year - 1982
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1982.tb00676.x
Subject(s) - cytotoxic t cell , rheumatoid arthritis , infiltration (hvac) , immunology , immunohistochemistry , antibody , t lymphocyte , immune system , t cell , inducer , synovial membrane , monoclonal antibody , staining , pathology , human leukocyte antigen , antigen , biology , medicine , in vitro , biochemistry , gene , physics , thermodynamics
An immunohistochemical double staining technique was used to study the relationships between HLA‐DR‐expressing, mostly macrophage‐like cells, and different populations of T lymphocytes in frozen sections of synovial tissue from patients with Inflammatory joint disease, particularly rheumatoid arthritis. Substantial T‐lymphocyte infiltration as measured by Leu I antibody binding was found, especially adjacent to HLA‐DR‐expressing cells near the synovial cavity and around small vessels. Most of the T cells reacted with Leu 3a ('helper/inducer'‐cell‐specific) antibodies, whereas relatively few cells were Leu 2a (cytotoxic/suppressor’ T‐cell‐specific)‐positive.