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Inhibition of T‐Cell Activity by Cyclosporin A
Author(s) -
ANDRUS L.,
LAFFERTY K. J.
Publication year - 1982
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1982.tb00670.x
Subject(s) - lipopolysaccharide , t cell , interleukin 2 , antigen , chemistry , immunology , microbiology and biotechnology , pharmacology , biology , immune system
Cyclosporin A (CyA) inhibits early events in the T‐ccll response. It strongly suppresses the activation of naive T cells by IL1 or IL2 and alloantigen. CyA exerts a selective effect on activ ated T cells, It inhibits the ability of these cells to release IL2 in response to antigen or mitogen restimulation, at concentrations that have no effect on the ability of these same cell populations to respond to IL2 by proliferation. The specific effects of CyA are not limited to T cells, however, and this drug will inhibit IL1 production by lipopolysaccharide W‐stimulated PU5‐IR cells.