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Induction of a Metallothionein‐like Protein in Human Lymphocytes
Author(s) -
ALEXANDER J.,
FØRRE Ø.,
AASETH J.,
DOBLOUG J.,
ØVREBØ S.
Publication year - 1982
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1982.tb00641.x
Subject(s) - phytohaemagglutinin , metallothionein , zinc , tuberculin , chemistry , phytohemagglutinins , microbiology and biotechnology , immunology , lymphocyte , biochemistry , biology , lymphocyte activation , medicine , immune system , pathology , tuberculosis , t cell , organic chemistry
Human peripheral lymphocytes were cultured in the presence of low (4μM) and high (100, 150 (μM) concenrations of zinc. Lymphocytes stimulated with phytohaemagglutinin (PHA) or tuberculin (PPD) synthesized metallothionein only in the presence of high concentrations of Zinc ions. Presence of a high zinc ion concentration alone did not stimulate the synthesis of DNA or of rnetallotnionein.