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Modulation of the Immune Response by Plasma Protease Inhibitors
Author(s) -
GRAVAGNA P.,
GIANAZZA E.,
ARNAUD P.,
NEELS M.,
ADES E. W.
Publication year - 1982
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1982.tb00629.x
Subject(s) - trypsin , alpha (finance) , protease , alpha 2 macroglobulin , cytotoxicity , cytolysis , inhibitory postsynaptic potential , chemistry , immune system , antibody , microbiology and biotechnology , biochemistry , biology , enzyme , macroglobulin , immunology , in vitro , medicine , endocrinology , construct validity , nursing , patient satisfaction
In two different cytolytic assays, dose‐dependent inhibition of antibody‐dependent cellmediated cytotoxicity and natural killing by alpha 2 ‐macroglobulin (α 2 m) and its subunits was observed. α 2 m subunits were approximately four times more inhibitory in both assays than the native 2 m molecule on a molar basis. Analysis of trypsin protein esterase activity demonstrated that α 2 m subunits were four times more active than the parent molecule.