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Modulation of the Immune Response by Plasma Protease Inhibitors
Author(s) -
ADES E. W.,
HINSON A.,
CHAPUISCELLIER C.,
ARNAUD P.
Publication year - 1982
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1982.tb00628.x
Subject(s) - antibody dependent cell mediated cytotoxicity , protease , alpha 2 macroglobulin , immune system , antibody , alpha (finance) , immunology , chemistry , biology , macroglobulin , virology , microbiology and biotechnology , enzyme , medicine , biochemistry , monoclonal antibody , construct validity , nursing , patient satisfaction
The two major protease inhibitors in human serum, alpha 1 ‐antitrypsin ( α1 AT) and alpha 2 ‐macroglobulin ( α2 m), were analysed for their effects on antibody‐dependent cell‐mediated cytotoxocity (ADCC) and natural killing (NK). The results indicate that both α1 AT and α2 m decrease ADCC and NK in a dose‐responsive pattern.