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Rabbit Spleen B Lymphocytes as Helper Cells in Lymphocyte Activation by Concanavalin A and Phtyohaemagglutinin
Author(s) -
CAVAILLON J.M.,
UDUPA T. N. S.,
CHOU C.T.,
CINADER B.,
DUBISKI S.
Publication year - 1982
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1982.tb00620.x
Subject(s) - phytohaemagglutinin , concanavalin a , microbiology and biotechnology , biology , lymphocyte , b cell , spleen , immunology , cell , antibody , in vitro , biochemistry
Using rosetting methods, we have purified rabit B cells and studied their interactions with T cells purified by passage over an anti‐immunoglobulin‐coated Degalan beads column. B cells enhance the responce of T cells in concanavalin A (Con A) and phytohaemagglutinin. In regulation of the response to Con A, an adherein cell is a third participating cell B‐cell preparations, contain a minority of cells that can respond to T mitogens with the help of non‐proliferating T cells, but the proportion of these responding cells is small, and the involvement of a T‐cell impurity cannot be excluded.