Premium
The Stimulus to Host Cell Proliferation in Graft‐versus‐Host Reactions
Author(s) -
FORD W. L.,
ROLSTAD B.,
FOSSUM S.,
HUNT S. V.,
SMITH M. E.,
SPARSHOTT S. M.
Publication year - 1981
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1981.tb00613.x
Subject(s) - host (biology) , major histocompatibility complex , histocompatibility , immunology , host response , biology , lymph node , graft versus host disease , t cell , graft vs host reaction , immune system , microbiology and biotechnology , antigen , stem cell , genetics , bone marrow transplantation , bone marrow , human leukocyte antigen
Two experiments are described concerned with the mechanism of host cell activation in the rat popliteal lymph node (LN) undergoing a graft‐versus‐host (GVH) reaction. (1) Irradiated, F 1 hybrid hosts (750 rad) mounted an impaired response to parental strain T cells. This was augmented by an intravenous injection of F 1 hybrid lymphocytes but not by parental strain B lymphocytes syngeneic with the initiating T cells. When the donor T cells (footpad) und B lymphocytes (intravenous) were completely allogeneic the residual response of the irradiated F 1 was completely inhibited. (2) The popliteal LN response in the semi‐allogeneic situation of the type (A × C)F 1 →(B × C)F 1 was, if anything, weaker than in the allogeneic situation AA→BB. These results and other data are discussed in terms of a possible major histocompatibility complex (MHC) requirement for host cell activation. The sharing of an MHC haplotype between donor and host cells is unlikely to be a necessary or sufficient condition for host cell activation.