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Human Interleukin 2: Production by Both T G Cells and Other T Cells
Author(s) -
SILVA A. G.,
ALVAREZ J. M.,
BONNARD G. D.,
LANDAZURI M. O.
Publication year - 1981
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1981.tb00570.x
Subject(s) - phytohaemagglutinin , receptor , interleukin 3 , interleukin 2 , microbiology and biotechnology , interleukin 21 , biology , stimulation , cytotoxicity , interleukin 12 , antibody , t cell , immunology , chemistry , cytotoxic t cell , immune system , in vitro , endocrinology , biochemistry
We have investigated the production of interleukin 2 (IL‐2) by human T cells after their stimulation by phytohaemagglutinin (PHA). T cells isolated by rosetting with sheep erythrocytes produced high levels of IL‐2. Further separation of rosette‐forming cells, according to the expression of Fc receptors for IgG, showed that T G and non‐T G cells are equally able to produce IL‐2. The release of IL‐2 by T G cells did not require DNA synthesis or functional Fey receptors, since positively selected T G cells produced IL‐2, even though they lacked lymphoproliferative responses to PHA and antibody‐dependent cell‐mediated cytotoxicity.