Premium
Delayed‐Type Hypersensitivity to Ovalbumin in Bone Marrow Chimeric Mice
Author(s) -
LUBET M. T.,
KETTMAN J. R.
Publication year - 1981
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1981.tb00563.x
Subject(s) - ovalbumin , bone marrow , immunology , major histocompatibility complex , effector , delayed hypersensitivity , chimera (genetics) , biology , limiting , medicine , antigen , gene , genetics , mechanical engineering , engineering
The site of action of the H‐2 linked gene regulating the ability of mice to be sensitized to transfer delayed‐type hypersensitivity was studied using radiation bone marrow chimeras. Lethally irradiated (non‐responder × responder) F 1 were reconstituted with bone marrow cells of both parents. Cells of chimeras immunized with limiting doses of ovalbumin responded as did the parental strains. These results suggest that the gene regulating delayed type hypersensitivity is expressed at the level of the delayed‐type hypersensitivity effector cells or that restrictions exits on the collaboration of the helper cells for DTH effectors (which differ at several loci including the major histocompatibility complex).